Chemistry Reference
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in
Figure 6.2
. All compounds produced a dose-dependent inhibition on growth of
the tumour cells evaluated. The order of activity in the catechol series with different
groups at position C18 was ester > acid ≥ alcohol. Compounds
14
and
17
exhibited
the strongest growth inhibitory effects, which were always higher than those presented
by carnosic acid for all the cancer cell lines tested. Nevertheless these catechols are
much less active than doxorubicin.
Scheme 6.4
Structure of catechols (
14
-
17
) and carnosic acid (
18
)
100
90
80
70
60
50
40
30
20
10
0
Doxorubicin
14
15
16
Compounds
17
18
Figure 6.2
IC
50
values of compounds (
14-18
). Data adapted from reference [17]
