Chemistry Reference
In-Depth Information
Table 6.1 Effects of abietic acid derivatives on the growth of human cancer
cell lines
Cell
Compound
HeLa
Vero
CC
50
R
2,a
CC
50
R
2
SI
1
14.9 ± 0.6
0.99
52.5 ± 5.6
0.92
3.5
3
3.6 ± 1
0.87
49.4 ± 3
0.98
13.7
4
5.2 ± 0.5
0.97
12.7 ± 2.4
0.76
2.4
5
5.6 ± 0.5
0.95
31.5 ± 6.5
0.80
5.6
6
53.1 ± 4.6
0.95
43.9 ± 4.7
0.94
0.8
7
46.6 ± 1.3
1
19.2 ± 1.8
0.92
0.4
8
19.7 ± 2.1
0.91
20.2 ± 1.5
0.95
1.0
9
33.4 ± 2.6
0.81
55.3 ± 2.2
0.99
1.6
Vincristine
0.05 ± 0.01
0.95
1.1 ± 0.2
0.95
22
a
coefficient of linear regression
Reproduced with permission from M.A.González, J. Correa-Royero, L. Agudelo, A.
Mesa and L. Betancur-Galvis,
European Journal of Medicinal Chemistry
, 2009,
44
,
2468. ©2007, Elsevier [14]
25
20
15
10
5
0
1
3
4
5
6
Compounds
7
8
9
Vincristine
Figure 6.1
SI values of compounds (
1-9
). Data adapted from reference [14]
