Bioreactor Design and Operation - Bioprocess Engineering: Kinetics, Biosystems, Sustainability and Reactor Design - page 912

CHAPTER
18

Bioreact or Design and O peration

OUTLINE

18.1. Bioreactor Selection 916 18.7.2.4. Thermal

Sterilization in
a Turbulent
Flow Tubular
Reactor

18.2. Reactor Operational Mode
Selection 921

18.3. Aeration, Agitation, and Heat
Transfer

941

923 18.7.3. Sterilization of Liquids 944

18.7.4. Sterilization of Gases 945

18.4. Scale-up 927

18.7.5. Ensuring Sterility 945

18.5. Scale-down 930

18.8. Aseptic Operations and Practical
Considerations for Bioreactor
System Construction

18.6. Bioinstrumentation and Controls 930
18.7. Sterilization of Process Fluids

946

932

18.8.1. Equipment, Medium
Transfer, and Flow Control 946
18.8.2. Stirrer Shaft

18.7.1. Batch Thermal Sterilization 933

18.7.2. Continuous Thermal
Sterilization

948

937

18.8.3. Fermentor Inoculation and
Sampling

18.7.2.1. Thermal
Sterilization in
a CSTR

948

18.8.4. Materials of Construction 949

937

18.8.5. Sparger Design 949

18.7.2.2. Thermal
Sterilization in
a PFR

18.8.6. Evaporation Control 949

18.9. Effect of Imperfect Mixing 950

938

18.9.1. Compartment Model 950

18.7.2.3. Thermal
Sterilization in
a Laminar Flow
Tubular Reactor

18.9.2. Surface Adhesion Model 952

18.10. Summary 957

940

Problems 961