Biomedical Engineering Reference
In-Depth Information
CHAPTER
11
How Cells Grow
OUTLINE
11.1. Quantifying Biomass
550
11.14. Overview of Microbial Growth
Kinetic Models
11.1.1. Cell Number Density
550
585
11.1.2. Cell Mass Concentration
551
11.14.1. Unstructured Growth
Models
587
11.1.2.1. Direct Methods
551
11.14.2. Simple Growth Rate
Model: Monod Equation 587
11.14.2.1. Modification
of Monod
Equation
with Growth
Inhibitors
11.1.2.2. Indirect
Methods
552
11.2. Batch Growth Patterns
553
11.3. Biomass Yield
558
11.4. Approximate Growth Kinetics
and Monod Equation
590
562
11.14.2.2. Multiple
Limiting
Substrates
11.5. Cell Death Rate
566
592
11.6. Cell Maintenance and
Endogenous Metabolism
11.14.3. Simplest Reaction
Network (or Simplest
Metabolic) Model
568
11.7. Product Yield
576
593
11.14.4. Simplest Metabolic
Pathway
11.8. Oxygen Demand for Aerobic
Microorganisms
594
577
11.14.5. Cybernetic Models
595
11.9. Effect of Temperature
580
11.14.6. Computational Systems
Biology
596
11.10. Effect of
P
H
582
11.15. Performance Analysis of Batch
Culture
11.11. Effect of Redox Potential
583
596
11.12. Effect of Electrolytes and
Substrate Concentration
11.16. Summary
599
583
Problems
601
11.13. Heat Generation by Microbial
Growth
584
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