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model for understanding the mechanical properties of intermediate
filaments in a variety of contexts, including the cytoskeleton of living
cells, as well as the fibre-reinforced composites known as
α
-keratins.
Studies of slime thread mechanics have also raised the intriguing
possibility that intermediate filaments in living cells may adopt
an amyloid-like structure under exceptional cases of mechanical
stress. If this is true, intermediate filaments may be important for
understanding the pathophysiology of conformational diseases,
especially those for which mechanical trauma is a significant risk
factor, such as Alzheimer's disease.
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