Biomedical Engineering Reference
In-Depth Information
Fig. 2.4
Root mean square fl uctuation (RMSF) for MMP2 catalytic site in 1QIB fi le
Gibbs Energy Landscape
800
0
200
400
600
800
600
400
200
0.5
0.0
0
Pc1
-0.5
-1.0
PC1
0.6
0.4
0.2
0.0
G(kJ/mol)
-0.2
0
15.9
-0.4
-0.6
-0.8
Pc2
0
123
6.11KT
Fig. 2.5
Free Gibbs energy landscape for MMP2 catalytic site with two substates separated by
less than 1KT
2.5
MMPs Natural Inhibitors
All MMPs are subject to natural inhibition by specific proteins called tissue inhibi-
tors of matrix metalloproteinases (TIMPs). TIMPs bind to MMP in 1:1 or 2:2 ratios.
TIMP-1 represents a more efficient inhibitor for MMP-1, MMP-3, and MMP-9 than
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