Biomedical Engineering Reference
In-Depth Information
CN
CN
C
5
H
12
CIN
+ n H
2
O
CH
2
C
+
n CH
2
nCH
2
O
n
COOEt
COOEt
CN
CN
CH
2
nH
2
C
C
COOEt
n
COOEt
Fig. 5.2
Synthesis of ethyl cyanoacrylate monomer (Et: CH
2
-CH
3
)
5.2.1.1
Polymerization of the Cyanoacrylate Monomers
Cyanoacrylate polymer films were prepared by adding water to the corresponding mono-
mers. 2 ml of cyanoacrylate monomer and 2 ml of distilled water (1:1 vol/vol) were
mixed in an polyethylene container under ambient conditions. Although the monomers
began to polymerize quickly when they came into contact with water, the polymerization
reactions lasted for 1 week. After taking out the polymer films from the remaining water,
they were maintained at room temperature for 24 h before characterization.
5.2.2
Experimental Techniques
5.2.2.1
Infrared Spectroscopy
The ATR-IR spectra of the cyanoacrylates were obtained in Tensor 27 Bruker spec-
trometer (Bruker Optik GmbH, Madrid, Spain). The attenuated total multiple
reflection method was employed (ATR-IR), and a diamond prism (Golden gate
device) was used; the incident angle of the IR beam was 45° and 60 scans were
obtained and averaged at a resolution of 4 cm
−
1
.
5.2.2.2
1
H and
13
C Nuclear Magnetic Resonance
Nuclear Magnetic Resonance (NMR) experiments were carried out in Bruker
AC-400 spectrometer (Bruker, Rheinstetten. Germany), provided with a magnet
of 400 MHz, dual probe
1
H/
13
C (5 mm), variable temperature unit, and automated
sample exchanger up to 60 samples. The experiments were carried out in special
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