Biomedical Engineering Reference
In-Depth Information
0.3
(A)
(B)
0.2
0.1
0
-0.1
-0.2
Shaker pulse
3
00
μ
m
5.3 ms
-0.3
-0.4
0 102030
Time (ms)
40
50
60
70
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90
100
90
80
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50
40
30
20
10
(C)
0.3
(D)
0.2
0.1
0
-0.1
-0.2
-0.3
-0.4
0 10203040
Time (ms)
50
60
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0
123
Frequency (kHz)
45 6
789 0
Figure 13.6
Surface waves due to shaker pulse in agar sample. (A) The amplitude data of the phase OCM
image at the detection point over time (black arrow points to the surface data selected to
analyze the phase change). (B) The phase change of the surface wave signal and waveform of
the shaker pulses on a 1% agar phantom. (C) The phase change of the detected system noise.
(D) The frequency contribution of the system noise and the detected surface wave signal.
Source: Taken with permission from Ref.
[16]
. Copyright of Optical Society of America.
present. From the phase-velocity graph, the elastic properties of different layers were
evaluated and shown to be in good agreement with the literature. This system has the
potential for clinical use in diagnosing dermis layer diseases and in other types of tissue
pathologies that change the elastic property of the tissue.
13.4.3 Motion Correction of Rodent Cerebral Cortex
Generally, during dynamic imaging in vivo, heart beat and breathing result in regular
movements, which are the main cause of image quality degradation. As the phase of the
SD-OCM signal is very sensitive to sample movements, these cardiac and respiratory
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