Biology Reference
In-Depth Information
Table 3. CaMKII substrates and interacting proteins in the PSD fraction
1
1. Data is summarized based on references (Yoshimura, et al., 2000 & 2002; see reviews, Fink &
Meyer, 2002; Griffith et al., 2003; Yamauchi, 2002 & 2005), with some additions.
5-1. Regulation of cytoskeleton: Dynamic processes and movement of
organelles and structural changes
Microtubule proteins are suitable substrates for CaMKII. Phosphorylation of MAP2 leads
to a reduction in affinity for tubulin, and induces microtubule disassembly (Yamauchi &
Fujisawa, 1983). The microtubule network plays an important role in maintaining cellular
morphology, in membrane interaction, in intracellular trafficking, and in establishing neurite
outgrowth of differentiating neurons (Drubin & Nelson, 1996).
Actin filament-microtubule interaction is also important for cellular structure, and the
interaction of actin filament with microtubules is regulated by phosphorylation-
dephosphorylation of MAP2. Phosphorylation of MAP2 by CaMKII inhibits the actin
filament cross-linking activity of MAP2, indicating that CaMKII regulates microtubule-
microfilament interaction (Yamauchi & Fujiswa, 1988). CaMKII also interacts with the tail
