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component of glutamatergic synaptic pathology in the hippocampal formation in these illness.
More studies are necessary to confirm this result that is a subject of debate [Dwork et al.,
2005].
Synaptic plasticity is thought to be important for learning and memory. Spinophilin may
play a role in CTA, a form of associative learning [Stafstrom-Davis et al., 2001] while
neurabin 1 seems to be involved in contextual fear conditioning [Wu et al., 2008]. It could be
interesting to thoroughly investigate the function of spinophilinin in hippocampal-
independent learning and memory mechanisms.
Learning and memory are higher-order brain functions involving several signalling
pathways and multiple partner proteins. Conditional transgenic and gene targeting
methodologies allowing spatial and temporal control over gene manipulations [Baumgartel et
al., 2007] may offer valuable tools for appropriate study of spinophilin and neurabin 1
functions in a specific brain area and in distinct temporal phases of synaptic plasticity.
R
EFERENCES
Allen, P. B., Ouimet, C.C., and Greengard, P. (1997). Spinophilin, a novel protein
phosphatase 1 binding protein localized to dendritic spines.
Proc. Natl. Acad. Sci
, USA.
94, 9956-9961.
Allen, P. B., Zachariou, V., Svenningsson, P., Lepore, A. C., Centonze, D., Costa, C., Rossi,
S., Bender, G., Chen, G., Feng, J., Snyder, G. L., Bernardi, G., Nestler, E. J., Yan, Z.,
Calabresi, P., and Greengard, P. (2006). Distinct roles for spinophilin and neurabin in
dopamine-mediated plasticity.
Neuroscience
, 140, 897-911.
Banke, T. G., Bowie, D., Lee, H. K., Huganir, R. L., Schousboe, A., and Traynelis, S. F.
(2000). Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase.
J. Neurosci
, 20, 89-102.
Barria, A., Muller, D., Derkach, V., Griffith, L. C., and Soderling, T. R. (1997). Regulatory
phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term
potentiation.
Science
, 276, 2042-2045.
Baumgartel, K., Fernandez, C., Johansson, T., and Mansuy, I. M. (2007). Conditional
transgenesis and recombination to study the molecular mechanisms of brain plasticity and
memory.
Handb. Exp. Pharmacol
. 178, 315-345.
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., and
Malenka, R. C. (2000). Regulation of AMPA receptor endocytosis by a signaling
mechanism shared with LTD.
Nature Neurosci
, 3, 1291-1300.
Bergson, C., Mrzljak, L., Smiley, J. F., Pappy, M., Levenson, R., and Goldman-Rakic, P. S.
(1995). Regional, cellular, and subcellular variations in the distribution of D1 and D5
dopamine receptors in primate brain.
J. Neurosci
, 15, 7821-7836.
Blitzer, R. D., Connor, J. H., Brown, G. P., Wong, T., Shenolikar, S., Iyengar, R., and
Landau, E. M. (1998). Gating of CaMKII by cAMP-regulated protein phosphatase
activity during LTP.
Science
, 280, 1940-1943.
Bollen, M. (2001). Combinatorial control of protein phosphatase-1.
Trends Biochem. Sci
., 26,
426-431.
