Biology Reference
In-Depth Information
Table 1. Effects of drug manipulations on the magnitude of LA-LTP
( increase; decrease)
Substance
Ltp
Nucleus
References
↑↓
Kainate
GLUR K5
LA
gender-dependent (Schubert et al. 2007)
GABA A agonists
GABA A antagonists
(Izquierdo and Medina 1995)
(Schubert and Albrecht 2007)
cytoskeletal-regulatory proteins
myosin light chain kinase
LA
(Lamprecht et al. 2006)
SK channels
LA
(Boucsein et al. 2001)
(Pollandt et al. 2003)
(Chen et al. 2003)
(Huang and Kandel 2007b)
Serotonin
5HT1A
5HT2
5HT4
LA
BLA
LA
Dopamine
LA
(Bissiere et al. 2003)
Norepinephrine
BLA
LA
BLA
LA
(Izquierdo and Medina 1995; Tully et al.
2007)
(DeBock et al. 2003)
(Huang et al. 2000)
α 2
ß
ACh (muscarinergic)
LA
(Watanabe et al. 1995a)
NO
LA
(Schafe et al. 2005)
COX-2
LA
(Albrecht 2007)
cannabinoid system
CB1
LA
(Azad et al. 2005)
gastrin-releasing peptide
LA
(Shumyatsky et al. 2002)
corticosterone
BLA
(Kavushansky and Richter-Levin 2006)
Renin-Angiotensin system
Angiotensin II
Angiotensin IV
Angiotensin-(1-7)
LA
LA
LA
(von Bohlen und Halbach and Albrecht
1998a; von Bohlen und Halbach and
Albrecht 2006) (Albrecht 2007)
VIII. P ATHOPHYSIOLOGICAL C HANGES IN P LASTICITY
A. Addiction to drugs
The amygdala plays key roles in several aspects of addiction to drugs of abuse. This brain
structure has been implicated in behaviors that reflect drug reward, drug seeking, and the
aversive effects of drug withdrawal.Using an animal model that involves repeated cocaine
Search WWH ::




Custom Search