Biology Reference
In-Depth Information
does not occur during the blockade [129]. After the removal of blockade, unexpectedly, CR
occurs from the beginning of reconditioning. Taken all these information together, although
cerebellar cortex is involved in some aspects of the eyeblink conditioning and that LTD at
parallel fiber - Purkinje cell synapse plays a role in the conditioning, an essential memory
trace seems to be formed and stored in the interpositus nucleus.
C
ONCLUSION
The cerebellar neural circuit has attracted neuroscientists over the last 40 years for its
structural simplicity and homogeneity. These features might make the cerebellum the first
CNS structure where the principle functioning rule and mechanism are clarified. Recent
studies have shown that various forms of synaptic plasticity are induced at various synapses
in the cerebellum, although their roles
in vivo
are enigmatic. Generation of mutant mice with
specific deficits together with the development of new techniques to monitor and/or
manipulate neuronal activity
in vivo
would contribute to the understanding of the roles of
each form of synaptic plasticity.
R
EFERENCES
[1] Fiez, J.A. (1996). Cerebellar Contributions To Cognition.
Neuron
, 16, 13-15.
[2] Cabeza, R., Nyberg, L. (2000). Imaging Cognition Ii: An Empirical Review Of 275 Pet
And Fmri Studies.
J Cogn Neurosci
, 12, 1-47.
[3] Llinas, R.R., Walton, K.d., Lang, E.J. (2004).
Cerebellum
. In: Shepherd Gm (Ed). The
Synaptic Organization Of The Brain: Oxford University Press; Pp. 271-309.
[4] Marr, D. (1969). A Theory Of Cerebellar Cortex.
J Physiol,
202, 437-470.
[5] Albus J. (1971). A Theory Of Cerebellar Function.
Math Biosci
, 10, 25-61.
[6] Ito, M., Sakurai, M., Tongroach, P. (1982). Climbing Fibre Induced Depression Of
Both Mossy Fibre Responsiveness And Glutamate Sensitivity Of Cerebellar Purkinje
Cells.
J Physiol
, 324, 113-134.
[7] Sakurai, M. (1987). Synaptic Modification Of Parallel Fibre-Purkinje Cell
Transmission In In Vitro Guinea-Pig Cerebellar Slices.
J Physiol,
394, 463-480.
[8] Hirano, T. (1990). Depression And Potentiation Of The Synaptic Transmission
Between A Granule Cell And A Purkinje Cell In Rat Cerebellar Culture.
Neurosci Lett
,
119, 141-144.
[9] Murashima, M., Hirano, T. (1999). Entire Course And Distinct Phases Of Day-Lasting
Depression Of Miniature Epsc Amplitudes In Cultured Purkinje Neurons.
J Neurosci
,
19, 7326-7333.
[10] Bliss, T., Collingridge, G. (1993). A Synaptic Model Of Memory: Long-Term
Potentiation In The Hippocampus.
Nature
, 361, 31-39.
[11] Llano, I., Marty, A., Armstrong, C., Konnerth, A. (1991). Synaptic- And Agonist-
Induced Excitatory Currents Of Purkinje Cells In Rat Cerebellar Slices.
J Physiol
, 434,
183-213.
[12] Piochon, C., Irinopoulou, T., Brusciano, D., Bailly, Y., Mariani, J., Levenes, C. (2007).
Nmda Receptor Contribution To The Climbing Fiber Response In The Adult Mouse
Purkinje Cell.
J Neurosci
, 27, 10797-10809.
