Biology Reference
In-Depth Information
disorders. Elucidating mechanisms that mediate the synaptic alterations under pathological
conditions may be of fundamental importance to understanding mechanisms of neuronal
injury.
Despite of many new findings there are still various questions to be answered and further
experiments to be done. The mechanisms of synaptic plasticity are still not completely clear
—the role of retrograde messengers, details in the molecular cascades leading to gene
expression and new protein synthesis or to growth of new synapses, finding the more accurate
causal connection between plasticity and various forms of learning, memory and cell damage.
The use of regulated and anatomically restricted genetic modification, combined with
morphologic analysis, should provide a powerful set of tools for elucidating synaptic
plasticity mechanisms.
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