Biomedical Engineering Reference
In-Depth Information
Table 2
Comparison of various methods of SLN preparation
S. No.
Name of the technique
Advantages
Disadvantages
References
High shear homogenisation and
ultrasonication
Simple technique, ease of prepara-
tion, use of low cost equipments, no
use of organic solvent
Broad size distribution of particles,
metal contamination may be there
if ultrasonication is used for longer
time
Vighia et al. (2013), Sharma et al.
(2010), Silva et al. (2012)
1.
2.
High pressure homogenisation
technique
Easy scaling up
Use of expensive equipments,
intense operating conditions,
huge amount of surfactants and
co-surfactants required
Silva et al. (2012)
Cold homogenisation
Appropriate for hydrophilic and
thermo-labile drugs
Large particle size obtained,
problem of scaling up, high shear
stress
Das et al. (2011), Neupane et al.
(2013)
Smaller particle size, ease of large
scale production
Temperature induced drug
degradation, complexity of
crystallization leading to
supercooled melts, dissolution of
drug into aqueous phase during
homogenisation resulting in
reduced concentration in SLN
Alhaj et al. (2008)
Hot homogenisation
Micro-emulsion based technique
Simple, cost effective, suitable for
heat sensitive drugs, avoidance of
organic solvent, reproducible prepa-
ration of SLN, higher entrapment
eficiency
Low nanoparticle concentration,
labour intensive process, larger
particle size
Ghadiri et al. (2011), Ramteke et al.
(2012)
3.
4.
Solvent-emulsiication/evapora-
tion technique
Reliable and simple technique,
reproducible results, homogeneous
preparations
Toxicity due to residual solvents,
long processing times, dificult to
scale up
Kushwahaet al. (2013),
Chattopadhyay et al. (2007)
(continued)
