Biomedical Engineering Reference
In-Depth Information
Fig. 20
Subcutaneous injection of (
top
) C-dots and (
bottom
) C
ZnS
-dots:
a
bright field,
b
,
d
as-detected fluorescence (excitation/emission wavelengths indicated), and
c
,
e
color-coded
images (Image from NIH). Adapted from Yang et al., with permission from American Chemical
Society. Copyright 2009
Fig. 21
Interdermal injection of C
ZnS
-dots:
a
bright field,
b
as-detected fluorescence, and
c
color-coded images.
Insets
dissected (in the
circled area
) axillary lymph node (LN). Adapted
from Yang et al., with permission from American Chemical Society. Copyright 2009
Taking advantage of bright green fluorescence of C
ZnS
-dots, they were further
employed for tracking the migration through lymph nodes. The harvested auxiliary
lymph nodes were dissected after 24 h post injection and exuded appreciable fluo-
rescence (Fig.
21
).
The circulation of C-dots in the whole body was studied through intravenous
injection into mice. After 3 h, bright fluorescence was observed in the urine, which
indicated that C-dots were cleared through urinary excretory pathway (Yang et al.
