Biomedical Engineering Reference
In-Depth Information
Fig. 1 a
Time-lapse near-IRfluorescence (NIRF) imaged mice bearing HCT-116 tumors after intra-
venous injections of IR-780 micelles.
b
NIRfluorescence intensities and contrast index (CI) values
were quantified at the indicated time points in the tumor and normal regions, using the maximal
NIRF signals in the nontumor regions.
c
Near-IRfluorescence (NIRF) images and
d
quantification
of various organs at 24 h after intravenous injection of IR-780 micelles. Each column represents the
mean (SD). The abbreviations indicate:
H
heart;
Li
liver;
Sp
spleen;
Lu
lung;
K
kidney; and
In
intes-
tine. Adapted from Peng et al., with permission from American Chemical Society. Copyright 2011
doxorubicin only in acidic environment prominently found in the vicinity of can-
cer cells (Zou et al. 2010).
1.1.2 PLGA Based Nanotheranostics
PLGA is one of the most extensively used biocompatible polymers for formulation
of a nanoscale theranostic systems. The therapeutic moieties delivered by such
