Biomedical Engineering Reference
In-Depth Information
13. Thomas, K.R. and Capecchi, M.R. (1987) Site-directed mutagenesis by gene targeting in mouse
embryo-derived stem cells.
Cell
,
51
, 503-512. Demonstration of homologous recombination in
ES cells by inserting a mutation into the
Hprt
wild-type locus.
14. Doetschman, T., Gregg, R.G., Maeda, N.
et al
. (1987) Targetted correction of a mutant HPRT gene
in mouse embryonic stem cells.
Nature
,
330
, 576-578. Demonstration of homologous recombi-
nation in ES cells by repairing the spontaneous
Hprt
mutation.
15. Thompson, S., Clarke, A.R., Pow, A.M.
et al
. (1989) Germ line transmission and expression of a
corrected HPRT gene produced by gene targeting in embryonic stem cells.
Cell
,
56
, 313-321.
16. Koller, B.H., Hagemann, L.J., Doetschman, T.
et al
. (1989) Germ-line transmission of a planned
alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination
in embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of
America
,
86
, 8927-8931.
17. Zijlstra, M., Li, E., Sajjadi, F.
et al
. (1989) Germ-line transmission of a disrupted
β
2
-microglobulin
gene produced by homologous recombination in embryonic stem cells.
Nature
,
342
, 435-438.
18. Thomas, K.R. and Capecchi, M.R. (1990) Targeted disruption of the murine int-1 proto-oncogene
resulting in severe abnormalities in midbrain and cerebellar development.
Nature
,
346
, 847-850.
19. Pease, S. and Williams, R.L. (1990) Formation of germ-line chimeras from embryonic stem
cells maintained with recombinant leukemia inhibitory factor.
Experimental Cell Research
,
190
,
209-211.
20. Mansour, S.L., Thomas, K.R. and Capecchi, M.R. (1988) Disruption of the proto-oncogene int-2 in
mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable
genes.
Nature
,
336
, 348-352. Application of a general positive-negative selection strategy to
enrich for cells in which homologous recombination has occurred.
21. Yagi, T., Ikawa, Y., Yoshida, K.
et al
. (1990) Homologous recombination at c-
fyn
locus of
mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.
Proceedings of the National Academy of Sciences of the United States of America
,
87
, 9918-9922.
22. Deng, C. and Capecchi, M.R. (1992) Reexamination of gene targeting frequency as a function of
the extent of homology between the targeting vector and the target locus.
Molecular and Cellular
Biology
,
12
, 3365-3371.
23. Te Riele, H., Maandag, E.R. and Berns, A. (1992) Highly efficient gene targeting in embryonic
stem cells through homologous recombination with isogenic DNA constructs.
Proceedings of the
National Academy of Sciences of the United States of America
,
89
, 5128-5132.
24. Nagy, A., Rossant, J., Nagy, R.
et al
. (1993) Derivation of completely cell culture-derived mice
from early-passage embryonic stem cells.
Proceedings of the National Academy of Sciences of the
United States of America
,
90
, 8424-8428. First description of the R1 line of ES cells.
25. Ledermann, B. and Burki, K. (1991) Establishment of a germ-line competent C57BL/6 embryonic
stem cell line.
Experimental Cell Research
,
197
, 254-258.
26. Noben-Trauth, N., Kohler, G., Burki, K. and Ledermann, B. (1996) Efficient targeting of the IL-4
gene in a BALB/c embryonic stem cell line.
Transgenic Research
,
5
, 487-491.
27. Valenzuela, D.M., Murphy, A.J., Frendewey, D.
et al
. (2003) High-throughput engineering of
the mouse genome coupled with high-resolution expression analysis.
Nature Biotechnology
,
21
,
652-659.
28. Poueymirou, W.T., Auerbach, W., Frendewey, D.
et al
. (2007) F0 generation mice fully derived
from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.
Nature Biotech-
nology
,
25
, 91-99.
