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Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD (2003) b -arrestin
mediated PDE4 cAMP phosphodiesterase recruitment regulates b 2 -adrenoceptor switching
from G s to G i . Proc Natl Acad Sci 100:940-945
Barnes P (2006) Theophylline for COPD. Thorax 61:742-744
Barnes AP, Livera G, Huang P, Sun C, O'Neal WK, Conti M, Stutts MJ, Milgram SL (2005)
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway
epithelium. J Biol Chem 280:7997-8003
Barren B, Gakhar L, Muradov H, Boyd KK, Ramaswamy S, Artemyev NO (2009) Structural basis
of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit. EMBO J
28:3613-3622
Bazhin AV, Tambor V, Dikov B, Philippov PP, Schadendorf D, Eichmuller SB (2010) cGMP-
phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+)
homeostasis in melanoma cells. Cell Mol Life Sci 67:817-828
Beavo JA, Brunton LL (2002) Cyclic nucleotide research - still expanding after half a century. Nat
Rev Mol Cell Biol 3:710-718
Beltman J, Becker DE, Butt E, Jensen GS, Rybalkin SD, Jastorff B, Beavo JA (1995) Characteri-
zation of cyclic nucleotide phosphodiesterases with cyclic GMP analogs: topology of the
catalytic domains. Mol Pharmacol 47:330-339
Bender AT, Beavo J (2006) Cyclic nucleotide phosphodiesterases: molecualr regulation to clinical
use. Pharmacol Rev 58:488-520
Bessay E, Blount M, Zoraghi R, Beasley A, Grimes K, Francis S, Corbin JD (2008) Phosphoryla-
tion increases affinity of the phosphodiesterase-5 catalytic site for tadalafil. J Pharmacol Exp
Ther 325:62-68
Blount MA, Beasley A, Zoraghi R, Sekhar KR, Bessay EP, Francis SH, Corbin JD (2004) Binding
of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays
potency, specificity, heterogeneity, and cGMP stimulation. Mol Pharmacol 66:144-152
Blount MA, Zoraghi R, Ke H, Bessay EP, Corbin JD, Francis SH (2006) A 46-amino acid
segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over
sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization. Mol Pharmacol
70:1822-1831
Blount MA, Zoraghi R, Bessay EP, Beasley A, Francis SH, Corbin JD (2007) Conversion of
phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors. J Pharmacol
Exp Ther 323:730-737
Bolger G, Michaeli T, Martins T, St John T, Steiner B, Rodgers L, Riggs M, Wigler M, Ferguson K
(1993) A family of human phosphodiesterases homologous to the dunce learning and memory
gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol
Cell Biol 13:6558-6571
Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie
GS, Houslay MD (2003) Attenuation of the activity of the cAMP-specific phosphodiesterase
PDE4A5 by interaction with the immunophilin XAP2. J Biol Chem 278:33351-33363
Bolger GB, Conti M, Houslay MD (2006) Cellular functions of phosphodiesterase-4 enzymes.
In: Beavo J, Francis S, Houslay MD (eds) Phosphodiesterases in health and disease. CRC, Boca
Raton, pp 99-130, Ch. 6
Bos JL (2006) Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci 31:680-686
Braumann T, Erneux C, Petridis G, Stohrer WD, Jastorff B (1986) Hydrolysis of cyclic nucleotides
by a purified cGMP-stimulated phosphodiesterase: structural requirements for hydrolysis.
Biochim Biophys Acta 871:199-206
Burgers PM, Eckstein F (1979) Stereochemistry of internucleotide bond formation by polynucle-
otide phosphorylase from Micrococcus luteus. Biochemistry 18:450-454
Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M,
Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME (2010) Design of phosphodi-
esterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat Biotechnol 28:63-70
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