Therapeutic Potential of Phosphodiesterase Inhibitors in Parasitic Diseases - Phosphodiesterases as Drug Targets - page 496

Table 1 Updated nomenclature of kinetoplastid PDEs (human pathogens only)
Enzyme
family

- Older

designations

Protein and gene
identification

Number References

Q388U6 (EMBL)
Tb10.389.0510 (TriTryp)

PDEA TbrPDEA TbPDE1 10 Kunz et al. ( 2004 ),

Gong et al.
( 2001 )

- TcrPDEA-P - Q309F4

Tc00.1047053511269.40

40 P -

- TcrPDEA-S TcrPDEA1 Q4E006

Tc00.1047053509805.20

40 S Alonso et al.

( 2007 )

- LmjPDEA - Q6S998

LmjF18.1090

18 Johner et al. ( 2006 )

- LinPDEA - A4HXY3

LinJ18.1100

18 -

- LbrPDEA - A4H9L9

LbrM18.0980

18 -

- - - - - -

PDEB TbrPDEB1 TbPDEC Q8WQX9

Tb09.160.3590

9 Zoraghi and

Seebeck
( 2002 ),
Oberholzer
et al. ( 2007 )

- TcrPDEB1 - Q4E0Y6

Tc00.1047053508277.100

7 S Diaz-Benjumea

et al. ( 2006 )

- LmjPDEB1 - Q6S996

LmjF15.1480 a

15 Johner et al. ( 2006 )

- LinPDEB1 - A4HWN7

LinJ15_V3.1550

15 -

- LbrPDEB1 - A4H8B6

LbrM15.1080

15 -

- - - - - -

- TbrPDEB2a TbPDE2B Q48F32

Tb09.160.3630

9 Rascon et al.

( 2002 ),
Oberholzer
et al. ( 2007 )

TbrPDEB2b b Q48F32 b

Tb09.160.3630

- - 9 Kunz et al. (2009a)

- TcrPDEB2-P - Q4CQR0

Tc00.1047053509943.20

7P -

- TcrPDEB2-S TcPDE1 Q4E0Y5

Tc00.1047053508277.110

7 S D'Angelo et al.

( 2004 )

- LmjPDEB2 - Q6S997

n.a.

n.a. -

- LinPDEB2 - A4HWN6

LinJ15_V3.1540

15 -

- LbrPDEB2 - A4H893

LbrM15.0880

15 -

- - - - - -

PDEC TbrPDEC - Q75ZK5

Tb03.27C5.640

3 -

TcrPDEC-P c - - n.a.

Tc00.1047053508153.520

36-P -

- TcrPDEC-S TcrPDEC 36 S Kunz ( 2005 )

( continued )