Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders - Phosphodiesterases as Drug Targets - page 466

Table 2 (continued)
PDE
inhibitors

Drug Model Task Results References

PDE4B knockout
mouse

Hole board test; light-dark
transition test; open-
field test

PDE4B knockout mouse decreases
head-dips and time spent in
head-dipping in the hole board
test, reduces transitions and time
on the light side in the light-dark
transition test, and decreases initial
exploration and rears in the
open-field test

Zhang et al. ( 2008 )

PDE4D knockout
mouse

Forced swim task; tail
suspension task

PDE4D knockout mouse exhibits
significant changes in associative
learning (i.e. fear conditioning)
and a reduction of immobility in
the tail suspension and forced
swim tasks

Rutten et al. ( 2008 ),
Zhang et al. ( 2002a , b )

PDE5 Sildenafil

(Viagra)

Muscarinic
acetylcholine
receptor antagonist
impaired rat

T-maze task Sildenafil ameliorates memory

deficits induced by a muscarinic
acetylcholine receptor antagonist

Devan et al. ( 2004 )

APP/PS1 transgenic
mouse

Fear conditioning task;
Morris water maze test

Sildenafil rescues synaptic and
memory (fear memory and
working memory) deficits in an
APP/PS1 transgenic mouse mode
of amyloid deposition

Puzzo et al. ( 2009 )

Modified elevated plus maze Sildenafil improves acquisition and

retention of memory in mice

Singh and Parle ( 2003 )

Vardenafil Tryptophan deleted rat Object recognition task Vardenafil attenuates the acute

tryptophan depletion induced
object recognition impairment

van Donkelaar et al.
( 2008 )