Biology Reference
In-Depth Information
Table 2 Overview of the effects of PDE inhibitors on mood and related cognitive disorders
PDE
inhibitors
Drug
Model
Task
Results
References
PDE1
Vinpocetine
Streptozotocin
impaired rat
Morris water maze test
Vinpocetine improves memory
consolidation
Deshmukh et al. (
2009
)
PDE2
BAY60-7550
MK-801 impaired
mouse
Object recognition task;
T-maze test
BAY60-7550 reverses MK801-
induced memory deficits
Boess et al. (
2004
)
Age-impaired rat
Object recognition task
BAY60-7550 improves acquisition
and consolidation
Domek-Łopaci´ska and
Strosznajder (
2008
)
Oxidative stress
impaired rat
Elevated plus maze;
open-field test
BAY60-7550 reverses the oxidative
stress induced anxiety-like
behaviors in mice
Masood et al. (
2008
)
ND7001
Oxidative stress
impaired rat
Elevated plus maze;
open-field test
ND7001 reverses the oxidative
stress induced anxiety-like
behaviors in mice
Masood et al. (
2008
)
PDE4
Rolipram
Scopolamine
impaired rat
Radial maze test
Rolipram reverses Scopolamine-
induced deficits in both working
memory and reference memory
Zhang and O'Donnell
(
2000
)
MK-801 impaired rat
Three-panel runway task;
radial-arm maze test;
passive avoidance test
Rolipram reverses the working
memory deficits caused by
MK-801
Zhang et al. (
2000
,
2005
), Reneerkens
et al. (
2009
)
Young rhesus monkey
T-maze test
Rolipram improves working
memory in young rhesus
monkeys but not in aged ones
Ramos et al. (
2003
)
Beta-amyloid
impaired rat
Morris water maze test;
passive avoidance test
Rolipram reverses memory deficits
induced by Abeta 25-35
Cheng et al.
2010
MEM1018
MK-801 impaired rat
Radial-arm maze test; step
through inhibitory
avoidance task
MEM1018 improves the
memory processes
Zhang et al. (
2005
)
MEM1091
MK-801 impaired rat
Radial-arm maze test; step
through inhibitory
avoidance task
MEM1091 improves the memory
process
Zhang et al.
2005
(
continued
)
