Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders - Phosphodiesterases as Drug Targets - page 451

Table 1 Distribution of PDE isoforms in the brain
Isoform Hippocampus Cortex Cerebellum Olfactory bulb Striatum Amygdala Hypothalamus References

PDE1A + + + + + Deshmukh et al. ( 2009 )

PDE1B + + + + +

PDE1C + + + +

PDE2A + + + + + + Boess et al. ( 2004 ), Nikolaev et al. ( 2005 )

PDE3A + + + + + + Bolger et al. ( 1994 )

PDE3B + + +

PDE4A + + + + + + + Zhan et al. ( 2003 ), Dlaboga et al. ( 2006 )

PDE4B + + + + +

PDE4C

PDE4D + + + + +

PDE5A + + + van Staveren et al. ( 2003 )

PDE6A Bender and Beavo ( 2006 )

PDE6B

PDE6C

PDE6D

PDE7A + + + + + P´rez-Torres et al. ( 2003 )

PDE7B + + + +

PDE8A Kobayashi et al. ( 2003 )

PDE8B + + + + +

PDE9A + + + + + + + van Staveren et al. ( 2001 , 2003 )

PDE10A + + + + Kelly et al. ( 2010 )

PDE11A + Kelly et al. ( 2010 )