Biology Reference
In-Depth Information
a high degree of specificity in PKA-mediated signaling despite the multiplicity of
receptors and targets using cAMP as a second messenger. Additional specificity is
obtained by integrating PDEs into these anchoring complexes and by the presence
of a large number of PDE isoforms distributed in different tissues and at varying
levels. The use of PDE-specific inhibitors has revealed that especially PDE4 iso-
forms are important drug targets in several diseases such as asthma, chronic
obstructive pulmonary disease (COPD), cardiovascular diseases, and neurological
disorders. In addition, PDEs are also interesting drug targets for immuosuppression
since cAMP potently inhibits immune functions.
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