Biology Reference
In-Depth Information
Acknowledgments The authors thanks members of the Froehner lab and Dr Kimberley Craven
for helpful discussions and suggestions. Research related to the role of nNOS and PDE5A
inhibitors in our laboratories is supported by the Muscular Dystrophy Association (JMP), Charlie's
Fund (SCF and JAB), Parent Project Muscular Dystrophy (JMP and SCF), NIH grants NS33145
(SCF), NS59514 (SCF and JAB), and AR056221 (SCF and JAB).
References
Adamo CM, Dai DF, Percival JM, Minami E, Willis MS, Patrucco E, Froehner SC, Beavo JA
(2010) Sildenafil reverses cardiac dysfunction in the
mdx
mouse model of Duchenne muscular
dystrophy. Proc Natl Acad Sci USA 107:19079-19083
Adams ME, Kramarcy N, Krall SP, Rossi SG, Rotundo RL, Sealock R, Froehner SC (2000)
Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in
utrophin. J Cell Biol 150:1385-1398
Adams ME, Mueller HA, Froehner SC (2001) In vivo requirement of the alpha-syntrophin PDZ
domain for the sarcolemmal localization of nNOS and aquaporin-4. J Cell Biol 155:113-122
Asai A, Sahani N, Kaneki M, Ouchi Y, Martyn JA, Yasuhara SE (2007) Primary role of functional
ischemia, quantitative evidence for the two-hit mechanism, and phospho-diesterase-5 inhibitor
therapy in mouse muscular dystrophy. PLoS One 2:e806
Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA,
Lemmon CA, Burnett AL, O'Rourke B, Rodriguez ER, Huang PL, Lima JA, Berkowitz DE,
Hare JM (2002) Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase
isoforms. Nature 416:337-339
Bendall JK, Damy T, Ratajczak P, Loyer X, Monceau V, Marty I, Milliez P, Robidel E, Marotte F,
Samuel JL, Heymes C (2004) Role of myocardial neuronal nitric oxide synthase-derived nitric
oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure
in rat. Circulation 110:2368-2375
Bender AT, Beavo JA (2006) Cyclic nucleotide phosphodiesterases: molecular regulation to
clinical use. Pharmacol Rev 58:488-520
Bia BL, Cassidy PJ, Young ME, Rafael JA, Leighton B, Davies KE, Radda GK, Clarke K (1999)
Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of
Duchenne muscular dystrophy. J Mol Cell Cardiol 31:1857-1862
Bloom TJ (2002) Cyclic nucleotide phosphodiesterase isozymes expressed in mouse skeletal
muscle. Can J Physiol Pharmacol 80:1132-1135
Bostick B, Yue Y, Long C, Marschalk N, Fine DM, Chen J, Duan D (2009) Cardiac expression of
a mini-dystrophin that normalizes skeletal muscle force only partially restores heart function in
aged mdx mice. Mol Ther 17:253-261
Boulanger CM, Heymes C, Benessiano J, Geske RS, L
ยด
vy BI, Vanhoutte PM (1998) Neuronal
nitric oxide synthase is expressed in rat vascular smooth muscle cells: activation by angiotensin
II in hypertension. Circ Res 83:1271-1278
Bredt DS, Snyder SH (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Proc Natl Acad Sci USA 87:682-685
Brenman JE, Chao DS, Xia H, Aldape K, Bredt DS (1995) Nitric oxide synthase complexed with
dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell
82:743-752
Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H,
Peters MF, Froehner SC, Bredt DS (1996) Interaction of nitric oxide synthase with the postsynap-
tic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 84:757-767
Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K,
McDonald C, Pandya S, Poysky J, Shapiro F, Tomezsko J, Constantin C, DMD Care
Considerations Working Group (2009) Diagnosis and management of Duchenne muscular
