Biology Reference
In-Depth Information
switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. J Biol
Chem 280:33178-33189
MacKenzie SJ, Baillie GS, McPhee I, Bolger GB, Houslay MD (2000) ERK2 mitogen-activated
protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phos-
phodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR
regions. J Biol Chem 275:16609-16617
McPhee I, Yarwood SJ, Scotland G, Huston E, Beard MB, Ross AH, Houslay ES, Houslay MD
(1999) Association with the SRC family tyrosyl kinase LYN triggers a conformational
change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B.
Consequences for rolipram inhibition. J Biol Chem 274:11796-11810
Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE,
Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ,
Houslay MD, Blackwood DH, Muir WJ, Porteous DJ (2005) DISC1 and PDE4B are interacting
genetic factors in schizophrenia that regulate cAMP signaling. Science 310:1187-1191
Monaco L, Vicini E, Conti M (1994) Structure of two rat genes coding for closely related rolipram-
sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing
and multiple start sites. J Biol Chem 269:347-357
Murdoch H, Mackie S, Collins DM, Hill EV, Bolger GB, Klussmann E, Porteous DJ, Millar JK,
Houslay MD (2007) Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes
to dissociation by elevated intracellular cAMP levels. J Neurosci 27:9513-9524
Naganuma K, Omura A, Maekawara N, Saitoh M, Ohkawa N, Kubota T, Nagumo H, Kodama T,
Takemura M, Ohtsuka Y, Nakamura J, Tsujita R, Kawasaki K, Yokoi H, Kawanishi M (2009)
Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett 19:3174-3176
Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS (2009) Mechanism for the allosteric
regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length
construct. Proc Natl Acad Sci U S A 106:18225-18230
Perez-Torres S, Miro X, Palacios JM, Cortes R, Puigdomenech P, Mengod G (2000) Phosphodi-
esterase type 4 isozymes expression in human brain examined by in situ hybridization
histochemistry and[3 H]rolipram binding autoradiography. Comparison with monkey and rat
brain. J Chem Neuroanat 20:349-374
Raymond A, Lovell S, Lorimer D, Walchli J, Mixon M, Wallace E, Thompkins K, Archer K,
Burgin A, Stewart L (2009) Combined protein construct and synthetic gene engineering for
heterologous protein expression and crystallization using Gene Composer. BMC Biotechnol
9:37
Reid P (2002) Roflumilast Altana Pharma. Curr Opin Investig Drugs 3:1165-1170
Richter W, Conti M (2002) Dimerization of the type 4 cAMP-specific phosphodiesterases is
mediated by the upstream conserved regions (UCRs). J Biol Chem 277:40212-40221
Robichaud A, Tattersall FD, Choudhury I, Rodger IW (1999) Emesis induced by inhibitors of type
IV cyclic nucleotide phosphodiesterase (PDE IV)
in the ferret. Neuropharmacology
38:289-297
Robichaud A, Savoie C, Stamatiou PB, Tattersall FD, Chan CC (2001) PDE4 inhibitors induce
emesis in ferrets via a noradrenergic pathway. Neuropharmacology 40:262-269
Robichaud A, Savoie C, Stamatiou PB, Lachance N, Jolicoeur P, Rasori R, Chan CC (2002a)
Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol 135:113-118
Robichaud A, Stamatiou PB, Jin SL, Lachance N, MacDonald D, Laliberte F, Liu S, Huang Z,
Conti M, Chan CC (2002b) Deletion of phosphodiesterase 4D in mice shortens alpha(2)-
adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.
J Clin Invest
110:1045-1052
Rocque WJ, Tian G, Wiseman JS, Holmes WD, Zajac-Thompson I, Willard DH, Patel IR,
Wisely GB, Clay WC, Kadwell SH, Hoffman CR, Luther MA (1997) Human recombinant
phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities. Biochemistry
36:14250-14261
Search WWH ::




Custom Search