Biology Reference
In-Depth Information
Table 1 Alignment of residues at the active sites of PDEs
159
160
164
200
201
204
273
318
319
321
322
329
333
336
337
340
357
368
369
372
373
376
406
Pde4D2
Y
H
H
H
D
H
M D
L
N
P
Y
T
I
M F
M S
Q
F
I
I
Y
Pde7
Y
H
H
H
D
H
I
D
I
N
P
S
S
V
T
F
L
I
Q
F
M L
W
Pde8
Y
H
H
H
D
H
M D
V
N
P
C
A
I
S
Y
V
S
Q
F
I
F
W
S/N/G
a
Pde1
Y
H
H
H
D
H
M D
I
H
P
H
T
L
M F
L
S
Q
F
I
I
Pde2
Y
H
H
H
D
H
L
D
L
D
Q
T
A
I
Y
F
M L
Q
F
M I
W
Pde3
Y
H
H
H
D
H
L
D
I
G
P
H
T
I
V
F
F
L
Q
F
I
I
W
Pde10A2 Y
H
H
H
D
H
L
D
L
S
V
T
A
I
Y
F
M G
Q
F
Y
V W
Pde11
Y
H
H
H
D
H
L
D
L
A
V
S
A
V
T
F
F
L
Q W I
I
W
Pde5
Y
H
H
H
D
H
L
D
L
A
I
Q
A
V
A
F
M M Q
F
I
I
W
pde6
Y
H
H
H
D
H
L
D
L
A
I
Q
A
V
A
F
M L
Q
F
I
V W
Pde9A2
F
H
H
H
D
H
M D
I
N
E
A
V
L
L
Y
F
A
Q
F
I
V
Y
b
b
b
b
The first row of the table is the amino acid number in PDE4D2
a
S/N/G represent Ser, Asn, and Gly in PDE1A, 1B, and 1C, respectively
b
Metal binding residues
