Information Technology Reference
In-Depth Information
Coverage
1
0.95
0.9
maximum
1lib
1lib (random)
2 libs
2 libs (random)
3 libs
3 libs (random)
0.85
0.8
0.75
0.7
0self0antigens
0self5antigens
2self2antigens
5self0antigens
5self5antigens
Description
maximum
1lib
random
stdev
2 libs
random
stdev
3 libs
random
stdev
0self0antigens
0.999
0.928
0.827
0.012
0.966
0.994
0.003
0.729
0.987
0.002
0self5antigens
0.996
0.979
0.828
0.031
0.995
0.978
0.004
0.943
0.961
0.019
2self2antigens
1.000
1.000
0.968
0.025
1.000
0.999
0.001
0.999
0.998
0.002
5self0antigens
1.000
1.000
0.983
0.006
1.000
1.000
0.000
0.901
1.000
0.000
5self5antigens
1.000
1.000
0.957
0.020
1.000
0.998
0.003
0.994
1.000
0.000
Fig. 7.
Coverage values for various cluster configurations and library sizes. In each case, the
theoretical maximum antigen coverage (against the given antigen set) is plotted against gene
library performance. The random coverage is the coverage achieved using random creation
of
the same number of antibodies
(see table 3).
Templates
25
20
self
antigen
1lib
1lib (random)
2 libs
2 libs (random)
3 libs
3 libs (random)
15
10
5
0
0self0antigens
0self5antigens
2self2antigens
5self0antigens
5self5antigens
description
self
antigen
1lib
Random
stdev
2lib
random
stdev
3lib
random
stdev
0self0antigens
19.70
6.00
21.98
20.38
0.35
4.20
9.57
0.14
3.11
12.51
0.26
0self5antigens
19.70
4.20
22.71
21.03
0.43
5.41
12.99
0.21
4.20
16.26
0.45
2self2antigens
10.27
3.28
17.60
17.58
0.41
2.37
10.52
0.16
1.38
9.15
0.08
5self0antigens
11.78
6.00
17.53
17.41
0.22
2.57
8.04
0.09
1.18
6.25
0.05
5self5antigens
11.78
4.20
19.20
19.07
0.38
2.89
10.35
0.15
1.16
7.03
0.05
Fig. 8.
Number of templates produced in self, antigen, evolved and randomly created libraries
