Biomedical Engineering Reference
In-Depth Information
Numerous investigators have shown that angiogenesis is controlled by sig-
naling proteins. For example, VEGF is known to promote recruitment of endo-
thelial cells, while PDGF promotes vessel stabilization and maturity (81).
Experiments show that including these and other growth factors in implanted
matrices does promote vascularization of the matrix (82). As with micro-
machined approaches, progress continues towards the final goal of creating en-
gineered vascularized tissue.
4.
CONCLUSION
The field of tissue engineering has developed rapidly in the past decade.
The generation of completely functional, implantable tissue-engineered organs
in the near future will be an enormous achievement in science and medicine, but
will require understanding and mastery of numerous processes affecting the cell
over multiple length scales.
5.
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