Biomedical Engineering Reference
In-Depth Information
Figure 13
. Raw particle images for the case of 0.5 (
a
) and 4.0 V (
b
).
response to applied electric fields can be quite complicated. It is becoming in-
creasingly popular to manipulate such suspended particles with electrical fields.
To fully understanding complexity science applied to biomedicine, one must
understand how particles behave at micrometer and nanometer length scales.
Experiments and modeling are often needed to determine not only the dominant
phenomenon (DEP vs. ETF) but also how the particles are distributed within the
flow. Particle distribution is of great importance in biological systems. Some-
times they need to be trapped near a wall for analysis and sometimes they need
to be kept away from walls to reduce fouling of a device.
6.
REFERENCES
1. Bousse L, Cohen C, Nikiforov T, Chow A, Kopf-Sill AR, Dubrow R, Parce JW. 2000. Elec-
trokinetically controlled microfluidic analysis systems [review].
Annu Rev Biophys Biomol
Struct
29
:155-181.
2. Chien R-L. 2002. Simultaneous hydrodynamic and electrokinetic flow control,
Micro Total
Anal Syst
1
:386-388.
3. Deval J, Tabeling P, Ho C-M. 2002. A dielectrophoretic chaotic mixer.
Proc IEEE MEMS
Workshop
, pp. 36-39.
4. Forster AH, Krihak M, Swanson PD, Young TC, Ackley DE. 2001. A laminated, flex structure
for electronic transport and hybridization of DNA.
Biosensors Bioelectron
16
(3):187-194.
5. Gascoyne PRC, Vykoukal J. 2002. Particle separation by dielectrophoresis [review].
Electro-
phoresis
23
(13):1973-1983.
6. Green NG, Ramos A, Morgan H. 2000. AC electrokinetics: a survey of sub-micrometre parti-
cle dynamics.
J Phys D Appl Phys
33
(6):632-641.
7. Green NG, Morgan H. 1998. Separation of submicrometre particles using a combination of
dielectrophoretic and electrohydrodynamic forces.
J Phys D Appl Phys
31
:L25-L30.
8.
Gurtner C, Tu E, Jamshidi N, Haigis RW, Onofrey TJ, Edman CF, Sosnowski R, Wallace B,
Heller MJ. 2002. Microelectronic array devices and techniques for electric field enhanced
DNA hybridization in low-conductance buffers.
Electrophoresis
23
:1543-1550.
