Biomedical Engineering Reference
In-Depth Information
Fatal vs. recoverable infection (user-specified option: does infected
Host die after infectious period?)
Duration of latency (user-specified option: Can an infected Host
cease being infectious after initial infectious period but resume be-
ing infectious at some later time point? If so, "reactivation from la-
tency" is realized as a random integer from a uniform probability
distribution with a user-supplied minimum and maximum value)
Operations
Replicate
D Expand the Pathogen population in this Host by a factor =
user-assigned growth rate / current host resistance
Progress Disease
D
With each execution of the Host's Age 1 Time Unit operation,
update the Pathogenic status by comparing duration of time
since infection with initialized values of (a) duration of latent
infectiousness, (b) duration of visible sickness, (c) duration of
latency, and (d) fatal vs. recoverable infection.
7.
NOTES
1."CDF Normal " denotes the Normal (mean = 0, SD = 1) cumulative distribu-
tion function mapping a real value from - to + into the probability range 0-1.
2."Inverse CDF Normal " denotes inversion of the CDF Normal function to map a
probability between 0 and 1 into a Standard Normal Deviate (mean = 0, SD = 1)
value ranging from - to +
8.
REFERENCES
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Biol 63 :139-165.
2. Dantzer R, Bluthé RM, Castanon N, Chauvet N, Capuron G, Goodall G, Kelley KW, Konsman
JP, Layé S, Parnet P, Pousset P. 2001. Cytokine effects on behavior. In Psychoneuroimmunol-
ogy , 3rd ed., pp. 703-727. Ed. R Ader, DL Felten, N Cohen. Academic Press, New York.
3. Hart BL. 1988. Biological basis of the behavior of sick animals. Neurosci Biobehav Rev
12 (2):123-137.
4. Anderson RM. 1982. The population dynamics of infectious diseases . Chapman and Hall, New
York.
5. Newman MEJ, Watts DJ, Strogatz SH. 2001. Random graph models of social networks. In
Technical report of the Santa Fe Institute . Santa Fe Institute, Santa Fe, NM.
6. Watts DJ, Strogatz SH. 1998. Collective dynamics of "small-world" networks. Nature
393 :440-442.
7.
Ader R, Cohen N, Felten D. 1995. Psychoneuroimmunology: interactions between the nervous
system and the immune system. Lancet 345 :99-103.
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