Biomedical Engineering Reference
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the therapy has its effect. Knowing the degree of diversity may help design the
best multi-modality therapies for a given tumor, taking into account the effects
of disturbance on diversity. Perhaps one day we will be able to determine what
therapeutic strategies are going to optimally alter tumor growth.
7.
ACKNOWLEDGMENTS
IGC acknowledges the support of a Ramon y Cajal research contract. This
work was also supported by grant NIH 113004 and by the Santa Fe Institute. Dr.
Isabel Gonzalez is now at the Department of Molecular Pathology, IDIBAPS,
Villarroel 170, 08036 Barcelona, Spain.
8.
REFERENCES
1. Jemal A, Thomas A, Murray T, Thun M. 2002. Cancer statistics 2002. CA Cancer J Clin
52:23-45.
2. National Cancer Institute. 2004. Cancer mortality maps and graphs (http://www3.cancer.gov/
atlasplus/charts.html).
3. Hahn WC, Weinberg RA. 2002. Modelling the molecular circuitry of cancer. Natl Rev Cancer
2 :331-341.
4. Mintz B. 1971. Clonal basis of mammalian differentiation. Symp Soc Exp Biol 25 :345-370.
5. Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shi IeM, Vogelstein B, Lengauer C.
2002. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA
99 :16226-16231.
6. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinszler KW, Vogel-
stein B. 1998. Mutations of miotic checkpoint genes in human cancers. Nature 392 :300-303.
7. Bardelli A, Cahill DP, Lederer G, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C. 2001.
Carcinogen-specific induction of genetic instability. Proc Natl Acad Sci USA 98 :5570-5775.
8. Nowell PT. 1976. The clonal evolution of tumor cell populations. Science 194 :23-28.
9. May RM. 1975. Stability and complexity in model ecosystems . Princeton UP, Princeton.
10. Case TJ. 2000. An illustrated guide to theoretical ecology . Oxford UP, Oxford.
11. Solé RV, Bascompte J. 1992. Stability and complexity in spatially extended two-species com-
petition. J Theor Biol 159 :469-480.
12. Tilman D. 1994. Competition and biodiversity in spatially structured habitats. Ecology 75 :2-
12.
13. Hanski, I. 1999. Metapopulation dynamics . Oxford UP, Oxford.
14.
Durrett R, Levin SA. 1994. Stochastic spatial models. Phil Trans Roy Soc London B 343 :329-
350.
15.
Gatenby RA. 1996. Application of competition theory to tumor growth: implications for tu-
mour biology and treatment. Euro J Cancer 32 :722-726.
16.
Gatenby RA. 1995. Models of tumor-host interactions as competing populations. J Theor Biol
176 :447-455.
17.
Tilman D. 1999. Diversity by default. Science 283 :495-496.
18.
Gonzalez-Garcia I, Solé RV, Costa J. 2002. Metapopulation dynamics and spatial heterogene-
ity in cancer. PNAS 99 :13085-13089.
19.
Levins, R. 1970. Extinction. Lect Notes Math 2 :75-107.
20.
Bascompte J, Solé RV. 1998. Modeling spatiotemporal dynamics in ecology . Springer, Berlin.
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