Biomedical Engineering Reference
In-Depth Information
Figure 3
. (
A
) A hypoxia-inducible factor 1
rule table, and (
B
) tokenized signal transduction.
The rules outlined in the table have been translated into a tokenized signaling pathway using
AND gates. These tables and pathways can be used to represent biocircuits. HIF-1
represents
a critical node in the cell's response to hypoxia.
repeat features of evolutionary history. During the Cambrian period there was a
great explosion of body types (48). Fossils from this epoch exhibit a far greater
variation in gross morphology than exists today. Likewise, a tumor, due to its
genetic pliability, can try innumerable cellular phenotypes, "searching" for the
one that can thrive in the current environment (host organ) or spread to different
environments (metastatic target organ), while discarding unfit cells. The fact that
