Biomedical Engineering Reference
In-Depth Information
This review of
in vitro
studies of nano-/microstructures substrates has demonstrated
their feasibility in promoting neural cell differentiation and neurite extension. Using the
scaffolds with ECM components, growth factors, and cells will further enhance their
potential to promote neurite outgrowth. Biofunctionalization of scaffolds with a cocktail
of bioactive molecules is required to achieve better cell engraftment. Controlling the
interaction with biological systems through the incorporation of nanotechnology and
tissue-inspired scaffolds enables cellular behavior
in vitro
or tissue regeneration
in vivo
to
be significantly improved.
References
[1] Brundin P, O Isacson, FH Gage and A Bjorklund (1986). Intrastriatal grafting of dopamine-
containing neuronal cell suspensions: effects of mixing with target or non-target cells. Brain
Research 389: 77-84.
[2] Doetsch F, I Caille, DA Lim, JM Garcia-Verdugo and A Alvarez-Buylla (1999). Subventricular
zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97: 703-716.
[3] Park KI, YD Teng and EY Snyder (2002). The injured brain interacts reciprocally with neural
stem cells supported by scaffolds to reconstitute lost tissue. Nature Biotechnology 20: 1111-1117.
[4] Recknor JB, DS Sakaguchi and SK Mallapragada (2006). Directed growth and selective
differentiation of neural progenitor cells on micropatterned polymer substrates. Biomaterials
27: 4098-4108.
[5] Santiago LY, RW Nowak, J Peter Rubin and KG Marra (2006). Peptide-surface modification of
poly(caprolactone) with laminin-derived sequences for adipose-derived stem cell applications.
Biomaterials 27: 2962-9.
[6] Song H, CF Stevens and FH Gage (2002). Astroglia induce neurogenesis from adult neural stem
cells. Nature 417: 39-44.
[7] Shen Q, SK Goderie, L Jin, N Karanth, Y Sun, N Abramova, P Vincent, K Pumiglia and
S Temple (2004). Endothelial cells stimulate self-renewal and expand neurogenesis of neural
stem cells. Science 304: 1338-1340.
[8] Lampe KJ, KB Bjugstad and MJ Mahoney (2010). Impact of degradable macromer content in
a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and
differentiation. Tissue Engineering Part A 16: 1857-1866.
[9] Saha K, AJ Keung, EF Irwin, Y Li, L Little, DV Schaffer and KE Healy (2008). Substrate mod-
ulus directs neural stem cell behavior. Biophysical Journal 95: 4426-4438.
[10]
Banerjee A, M Arha, S Choudhary, RS Ashton, SR Bhatia, DV Schaffer and RS Kane (2009).
The influence of hydrogel modulus on the proliferation and differentiation of encapsulated
neural stem cells. Biomaterials 30: 4695-4699.
[11]
Noble M, J Smith, J Power and M Mayer-PrÖSchel (2003). Redox state as a central modulator
of precursor cell function. Annals of the New York Academy of Sciences 991: 251-271.
[12]
Gage FH, G Kempermann, TD Palmer, DA Peterson and J Ray (1998). Multipotent progenitor
cells in the adult dentate gyrus. Journal of Neurobiology 36: 249-266.
[13]
Lutolf MP and JA Hubbell (2005). Synthetic biomaterials as instructive extracellular microen-
vironments for morphogenesis in tissue engineering. Nature Biotechnology 23: 47-55.
[14]
Barros CS, SJ Franco and U Muller (2011). Extracellular matrix: functions in the nervous
system. Cold Spring Harbor Perspectives in Biology 3: a005108.
[15]
Talac R, JA Friedman, MJ Moore, L Lu, E Jabbari, AJ Windebank, BL Currier and MJ Yaszemski
(2004). Animal models of spinal cord injury for evaluation of tissue engineering treatment strat-
egies. Biomaterials 25: 1505-1510.
[16]
Kerrigan JJ, JP Mansell and JR Sandy (2000). Matrix turnover. Journal of Orthodontics 27:
227-233.
[17]
Gao X, Y Wang, J Chen and J Peng (2013). The role of peripheral nerve ECM components in
the tissue engineering nerve construction. Reviews in Neuroscience 24: 443-453.
