Biomedical Engineering Reference
In-Depth Information
Table 13.1
Recently reported organic nanocarriers for bioactive agent delivery into stem cells
Origin
Type
Bioactive agent
Cell type
Year
Reference
Synthetic
PEI
RA
mESC
2013
[10]
Cyclodextrin-
modified dendrimer
siRNA
NSC
2013
[19]
Cystamine- PBAE
siRNA
MSC
2012
[30]
Branched PDA
siRNA
MSC
2012
[44]
Diblock copolymer
siRNA
MSC
2012
[11]
PLGA-PEI
DNA/siRNA
hMSC
2012
[39]
Acetylated-PEI
DNA
MSC
2008
[16]
PAMAM
DNA
MSC
2008
[18]
Peptide-functionalized
dendrimer
DNA
MSC
2010
[20]
PAMAM dendrimer
DNA
MSC
2010
[21]
Peptide-functionalized
dendrimer
DNA
MSC
2011
[22]
dPAMAM
DNA
rMSC
2009
[23]
PBAE
DNA
hMSC
2009
[28]
PBAE
DNA
hESC
2008
[29]
PBAE
DNA
MSC
2011
[31]
PLGA
DNA
hMSC
2011
[38]
PLGA-PEI
DNA
hCBMSC
2008
[36]
PLGA-PEI
DNA
hMSC
2011
[37]
PEG-graft-PEI
DNA
MSC
2011
[15]
PBCA
DNA
iPSC
2013
[46]
Natural
Dextran/PEI
RA
SVZNSC
2013
[9, 17]
CS/dendrimer
Dex
rBMSC
2009
[42]
CS/PEI
DNA
rMSC
2010
[40]
HA/Branched PEI
DNA
MSC
2011
[14]
HA/Branched PEI
DNA
hMSC
2008
[43]
CS
DNA
hMSC
2003
[41]
PEI, polyethylenimine; PBAE, poly(
β
-amino ester); PDA, poly(disulfide amine); PLGA, poly(lactide-co-gly-
colide); dPAMAM, partially degraded PAMAM dendrimer; PEG, polyethylene glycol; PBCA, polybutylcyano-
acrylate; CS, chitosan; RA, retinoic acid; Dex, dexamethasone; mESC, murine embryonic stem cell; NSC,
neural stem cell; hCBMSC, human cord blood-derived mesenchymal stem cell; rBMSC, rat bone-marrow
stromal cell; iPSC, induced pluripotent stem cell; SVZNSC, subventricular zone neuronal stem cells.
different pHs as well as the effect of RA-nanoparticles on cell proliferation and functional
neuronal differentiation. Their intent was to assess the effectiveness of this delivery system.
In another study [17], the same group investigated the application of complex nanoparticles
as a vehicle to induce the neuronal differentiation of subventricular zone NSCs. This intra-
cellular delivery system activates nuclear RA receptors, decreases stemness, and increases
proneugenic gene expression.
Recently, Ku
et al
. [10] synthesized functional RA−PEI complex nanoparticles from
branched PEI chains with carboxyl groups of RA surfaces by electrostatic interaction to
