Environmental Engineering Reference
In-Depth Information
actuators, such as “on-off” valves, to control the flow and delivery of chemical reagents. The main component of mechanical
actuators that gives it the switching capability is the responsive material that is capable of undergoing conformational changes
in response to different stimuli. Responsive materials can respond to bulk and/or localized stimuli, where, for applications
controlling cellular microenvironment conditions, it is necessary to use responsive materials to localized triggers. being
optically responsive materials, which is the most used and appropriate option for this application, thermally responsive polymer-
metal nanocomposites offer the best option for use as the optical switching component of “on-off” valves. The challenges that
arise are the synthesis pathways to couple both metal particles and the responsive polymer. A solution proposed is to take
advantage of the previously reported interaction of N- and o-containing compounds, such as PNIPAM, with different metals,
such as silver and gold, to perform a wet chemistry
in situ
reduction of metallic salts and achieve stable, well-controlled parti-
cles coupled with the responsive polymer. lastly, different methodologies to incorporate the developed nanocomposites into
nanoporous membranes can be addressed which in future work will be used as optothermally responsive nanovalves in
in vitro
cell culture systems to control the delivery of reagents and
in vivo
-like conditions of the microenvironments.
successful development of these cell culture systems will have a profound impact on the development of pathways to drug
discovery and novel therapeutics of diseases that develop due to cellular malfunction such as cancer and diabetes.
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