The Dos Family of Globin-Related Sensors Using PAS Domains to Accommodate Haem Acting as the Active Site for Sensing External Signals - Advances in Microbial Physiology - page 271

CHAPTER SEVEN

The Dos Family of Globin-Related
Sensors Using PAS Domains to
Accommodate Haem Acting
as the Active Site for Sensing
External Signals

Shigetoshi Aono 1
Okazaki Institute for Integrative Bioscience & Institute for Molecular Science, National Institutes of Natural
Sciences, Okazaki, Japan
1 Corresponding author: e-mail address: [e-mail]

Contents
1. Introduction 275

2. General Properties of PAS Domains 276

3. Single-Component Systems for Transcriptional Regulation 276

3.1 CO oxidation operon 276

3.2 Regulator of CO metabolism 278

3.3 Neuronal PAS domain 2 protein 280

4. Two-Component Systems for Transcriptional Regulation 281

4.1 FixL/FixJ two-component system 281

4.2 A haem-based redox sensor in NtrY/NtrX two-component system 294

4.3 DosS and DosT using a haem-containing GAF domain as a sensor module 295

5. Haem-Containing PAS Family for the Regulation of Diguanylate Cyclases and
Phosphodiesterases 298

5.1 Regulation of diguanylate cyclases activity through interactions between
haem and external ligand

298

5.2 PDEs consisting of a haem-containing PAS and EAL domains 301

5.3 A haem-sensing PAS domain regulates the PDE activity of YybT 305

6. Haem-Containing PAS Family for Chemotaxis Regulation 307

6.1 Bacterial chemotaxis system 307

6.2 MCP containing a PAS domain with b-type haem 308

6.3 MCP containing a PAS domain with c-type haem 311

7. Conclusion 316

References 317