Biology Reference
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Figure 5.5—Cont'd Structure based sequence alignment of Type I (A) and Type II (B)
flavohemoglobins of mycobacteria. Conserved regions and co-factor binding sites are
highlighted and shown in boxes.
peroxidase-like imidazolate character present in a typical flavoHb (
Gupta
et al., 2012
). Thus, the architecture and the redox properties of Mycobac-
terial Type II flavoHbs might be distinct from other microbial flavoHbs. The
reductase domain of Type II flavoHbs of Mycobacteria is also modified and
devoid of critical residues needed for the binding of co-factors FAD and
NADH. For example, the RxYS motif, the hall mark of FAD binding,
