Biology Reference
In-Depth Information
Table 5.1 Distribution of truncated haemoglobins and flavohaemoglobins among
various species of Mycobacteria
—
Cont'd
FlavoHbs
Mycobacterium
species
Type I (E. coli
type)
Type II (Mtb
type)
trHbN trHbO trHbP
Status
Mycobacterium
hassiacum
1
1
-
-
1
Avirulent
Mycobacterium ulcerans
1
1
1
1
1
Virulent
Mycobacterium sp.
MOTT36Y
1
1
1
-
1
Virulent
Mycobacterium sp.
JDM 6-1
1
1
-
-
1
Virulent
Mycobacterium
chubuense
1
1
-
1
1
Virulent
Mycobacterium
colombiense
1
1
1
-
-
Virulent
Mycobacterium
thermoresistibile
-
1
1
1
1
Virulent
Mycobacterium vaccae
1
1
-
1
-
Avirulent
Mycobacterium tusciae
1
1
1
-
1
Virulent
Mycobacterium phlei
1
1
-
1
1
Avirulent
Mycobacterium
parascrofulaceum
1
1
1
-
1
Virulent
Mycobacterium
fortuitum
1
1
1
1
1
Virulent
3. trHbs OF MYCOBACTERIA: SMALL Hbs WITH
NOVEL CHARACTERISTICS
Unsurprisingly, considering their name, trHbs are smaller than typical
Hbs, usually by around 20-40 residues. However, contrary to what the
name suggests, they are not simply 'truncated' versions of conventional glo-
bins: their structures are based on a 2-on-2
-helical fold that contributes to
the stability of the protein. As
Wittenberg et al. (2002)
explain, trHbs show a
universal conservation of the helix pairs B/E and G/H, deletion of almost
a
