Biomedical Engineering Reference
In-Depth Information
functionalized cell, for example a magnetically targeted “ cancer - seeking ” mono-
cyte [106]. A greater in-depth knowledge of magnetosome formation should facili-
tate the approach to synthesizing enhanced magnetosomes or magnetosome - inspired
biomimetic nanomagnetic materials. For example, the biomineralization/iron-
binding/scaffold protein Mms6 can control the size and shape of nanoparticulate
magnetite
in vitro
in a chemical precipitation. It follows that, the greater the
number of biomineralization proteins that can be identifi ed, overexpressed, puri-
fi ed, and their function ascertained, the more the biomineralization process can
be used
in vitro
to impose a precise biological control over particle size and shape.
This should lead, eventually, to systems whereby specifi c combinations of proteins
are applied, depending on the particle's tailored specifi cations, to produce high-
yield, high-quality, customized nanomagnetic particles.
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