Biomedical Engineering Reference
In-Depth Information
body, and this will undoubtedly contribute signifi cantly to the fi eld of regenerative
medicine.
The ability to manipulate cellular processes remotely via nanomagnetic actua-
tion opens up myriad opportunities not only for the mechanical conditioning of
cells and tissue constructs within bioreactors and
in vivo
, but also for stem cell
targeting and differentiation. Although many investigations must still be con-
ducted in order to realize the potential of these techniques and, in many ways,
this fi eld is still in its infancy, rapid progress is already leading us in directions
considered impossible just a decade ago.
References
1
Ito , A. and Honda , H. ( 2006 ) Magnetic
nanoparticles for tissue engineering, in:
Nanotechnologies for the Life Sciences
,
(ed. C. Kumar ), Vol. 9, pp. 308 - 37 .
2
Pankhurst , Q.A. , Connoly , J. , Jones , S.K.
and Dobson , J. ( 2003 ) Applications of
magnetic nanoparticles in biomedicine.
Journal of Physics
,
36
, R 167 - 181 .
3
Dobson , J. ( 2006 ) Gene therapy progress
and prospects: magnetic nanoparticle-
based gene delivery.
Gene Therapy
,
13
,
283 - 7 .
4
Weissleder , R. , Elizondo , G. , Wittenberg ,
J. , Rabito , C.A. , Bengele , H.H. and
Josephson , L. ( 1990 ) Ultrasmall
superparamagnetic iron oxide:
characterization of a new class of contrast
agents for MR imaging.
Radiology
,
175
,
489 - 93 .
5
McBain , S.C. , Yiu , H.H. and Dobson , J.
(2008) Magnetic nanoparticles for gene
and drug delivery.
International Journal of
Nanomedicine
,
3
, 169 - 80 .
6
Neuberger , T. , Schopf , B. , Hofmann , H. ,
Hofmann , M. and von Rechenberg , B.
( 2005 ) Superparamagnetic nanoparticles
for biomedical applications: possibilities
and limitations of a new drug delivery
system .
Journal of Magnetic Materials
,
293
,
483 - 96 .
7
Langer , R. and Vacanti , J.P. ( 1993 ) Tissue
engineering .
Science
,
260
, 920 - 6 .
8
Dobson , J. ( 2008 ) Remote control of
cellular behavior with magnetic
nanoparticles .
Nature Nanotechnology
,
3
,
139 - 43 .
9
Crick , F. ( 1950 ) The physical properties of
cytoplasm. A study by means of the
magnetic particle method part II.
Experimental Cell Research
,
1
, 505 - 33 .
10
Gehr , P. , Brain , J.D. , Bloom , S.B. and
Valberg , P.A. ( 1983 ) Magnetic particles in
the liver: a probe for intracellular
movement .
Nature
,
302
, 336 - 8 .
11
Gehr , P. , Brain , J.D. and Bloom , S.B.
(1984) Noninvasive studies of Kupffer
cells in situ by magnetometry.
Journal of
Leukocyte Biology
,
35
, 19 - 30 .
12
Valberg , P.A. and Feldman , H.A. ( 1987 )
Magnetic particle motions within living
cells. Measurement of cytoplasmic
viscosity and motile activity.
Biophysical
Journal
,
52
, 551 - 61 .
13
Valberg , P.A. and Butler , J.P. ( 1987 )
Magnetic particle motions within living
cells. Physical theory and techniques.
Biophysical Journal
,
52
, 537 - 50 .
14
Valberg , P.A. and Albertini , D.F. ( 1985 )
Cytoplasmic motions, rheology, and
structure probed by a novel magnetic
particle method.
The Journal of Cell
Biology
,
101
, 130 - 40 .
15
Valberg , P.A. , Meyrick , B. , Brain , J.D. and
Brigham , K.L. ( 1988 ) Phagocytic and
motile properties of endothelial cells
measured magnetometrically: effects of
endotoxin .
Tissue Cell
,
20
, 345 - 54 .
16
Wang , N. , Butler , J.P. and Ingber , D.E.
( 1993 ) Mechanotransduction across the
cell surface and through the cytoskeleton.
Science
,
260
, 1124 - 7 .
17
Bausch , A.R. , Ziemann , F. , Boulbitch ,
A.A. , Jacobson , K. and Sackmann , E.
( 1998 ) Local measurements of
viscoelastic parameters of adherent
cell surfaces by magnetic bead
