Biomedical Engineering Reference
In-Depth Information
Table 4.2
Continued
Targeted
contrast media
Coating agent
Characteristics
Pharmacophore
Biological target
Reference(s)
MION -
antibody
Dextran
D
= 8.3,
r
2
= 24 -
29 m
M
− 1
s
− 1
, 1.5 T
Monoclonal antibody
anti - Her2/neu
Her2/neu
receptors in
tumors
[161]
MION -
antimyosin
Dextran
r
1
= 10.1 and
r
2
= 120 m
M
− 1
s
− 1
0.47 T
Monoclonal antibody
Antimyosin
Fab (R
11
D
10
)
Myocardial
infarction
[293]
SPIO - annexin
V
Dextran
D
h
= 100 nm
Annexin V
Atherosclerotic
plaque
[238]
USPIO - RGD
Carbohydrate
ND
Cyclic RGD peptide
[155]
α
3
- , thrombus
imaging
IIB
β
USPIO Fe
3
O
4
/
trypsin
Amino -
groups
r
1
= 6.31 and
r
2
= 8.33 m
M
− 1
s
− 1
9.4 T
Oligonucleotides and
trypsin
Kupffer cells and
liver
[111]
CLIO - SC - Tf
CLIO - NH
2
r
1
= 32 and
r
2
= 144 m
M
− 1
s
− 1
0.47 T
Transferrin
Transferrin
receptors
[309]
CLIO - Tat
CLIO - NH
2
r
1
= 22 and
r
2
= 72 m
M
− 1
s
− 1
0.47 T,
D
h
= 42
Tat peptide
Lymphocyte
uptake
[272]
CLIO - antibody
CLIO - NH
2
D
h
= 40 nm
Mouse - anti - human E
selectin antibody
fragment
Infl ammation
[310]
CLIO - Cy5.5 -
cRGD
CLIO - Cy5.5 -
NH
2
D
h
= 29 - 39 nm
Cyclic RGD peptide
[311, 312]
α
V
β
3
integrin
CLIO - SC -
R4Cy5.5
CLIO - NH
2
r
1
= 29.9 and
r
2
= 92.5 m
M
− 1
s
− 1
0.47 T,
D
h
=62
RRRRGC peptide and
Cy5.5
Cathepsin B
[313]
±
7 nm
USPIO - folate
Silane - PEG -
trifl uoroethyl-
ester
D
= 9 - 11 nm
(TEM)
Folic acid
Folate receptor
[94]
