Biomedical Engineering Reference
In-Depth Information
surfactant contains its own impurities, this will prevent an accurate analysis and
result in analytical errors [41]. Therefore, multiple analytical results using a variety
of tools should be sought when separating nanomaterials in microfl uidic devices.
3.5.3
Isomagnetophoresis ( IMP )
Since the magnetic susceptibility of a material is determined by a combination of
constituent elements, electrons, chemical bond, and bond- bond interaction [111] ,
thereby revealing information about a molecule's properties and composition, this
characteristic has been widely studied in several research fi elds, including materi-
als science [112] and biomedical research [113, 114]. As a novel principle, isoelec-
trophoresis (IEP), which has been widely used in molecular biology and analytical
biochemistry, can be dedicated to improvements of the current magnetophoretic
analysis techniques. On the other hand, isomagnetophoresis ( IMP ) can be dem-
onstrated by generating the magnetic susceptibility gradient across the microfl u-
idic channel, where the magnetic fl ux density gradient also exists. As shown
in Figure 3.21, IMP enables one to discriminate the subtle difference in the
magnetic susceptibility, which cannot be distinguished by using conventional
Figure 3.21
Schematic of isomagnetophoretic discrimination
process of particles having subtle difference of magnetic
susceptibility (
Δ
χ
) in a microfl uidic channel. Reproduced with
permission from Ref. [42]; © 2008, American
Chemical Society.
