Biology Reference
In-Depth Information
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A
Time (days)
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B
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FIGURE 5-10.
BG fluctuations in T1DM vs. T2DM. Panel A shows the greater variation of BG levels in T1DM and
panel B shows the BG levels in a patient with T2DM. (From Kovatchev, B. P., Cox, D. J., Gonder-
Frederick, L. A., & Clarke, W. L. [2002]. Methods for quantifying self-monitoring blood glucose
profiles exemplified by an examination of blood glucose patterns in patients with type 1 and 2
diabetes. Diabetes Technology and Therapeutics, 4, 295-303. Used by permission.)
T2DM for 14 years. Each figure presents 30 days of SMBG data,
representing 90 readings collected, an average of three times per day.
As is evident from the graphs, the BG levels for both subjects fluctuate
about comparable average values. This was confirmed by their
practically identical HbA
1c
values (9.1% for patient A versus 9.2% for
patient B), reflecting the average BG control throughout the study. This
comparison confirms once again that average BG levels cannot be used
to quantify BG fluctuations. Therefore, one possible validation of the BG
risk indices would be to demonstrate their capability of quantitatively
describing the increased risk for hypo- and hyperglycemia associated
with such fluctuations.
Indeed, after computing the LBGI and HBGI for both patients, we
found the LBGI and HBGI of patient A (T1DM) were both substantially
