The Temporal Sequence of Changes in Gene Expression by Drugs of Abuse - Drugs of Abuse: Neurological Reviews and Protocols - page 7

in gene expression and neuronal function in these brain regions following a
bout of drug-taking. Although the studies outlined in this chapter are promising
in pointing to a common point of intervention in addiction to various chemical
classes of drugs, it is important to note that such a generalization based
primarily on work with psychostimulants is premature, and verifi cation will
require substantially more research using other classes of drugs. Also, the
temporal sequence of neuroadaptive changes during drug withdrawal points
to the possible utility of targeting different pharmacotherapies at different
stages of withdrawal. Thus, in early withdrawal drugs affecting dopamine
transmission may be more effective, while in later withdrawal modulation of
glutamate transmission may be more effi cacious.
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