Biomedical Engineering Reference
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Fig. 1. Baseline EEG and neck EMG recordings were taken for 2 d prior to injections
of saline or MDMA (10 mg/kg, i.p. every 2 h for a total of four injections). The data
presented are those from recordings obtained 7 d after MDMA treatment and are
expressed as percent of the baseline recordings taken prior to MDMA treatment.
Differences in the strain of rat used in these studies may account for differences
in behavior.
Importantly, reduction in social interaction in MDMA-treated rats may not
be related to depletion of brain 5-HT. Social interaction is reduced in rats
treated with a moderate dosage regimen of MDMA that does not produce 5-HT
neurotoxicity
(96)
and in rats treated on postnatal d 39
(98)
, at which time
rats are insensitive to 5-HT neurotoxicity induced by MDMA
(41
,
62)
. Thus,
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