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Fig. 8.8 Many members of Cluster #7 are found to have citation bursts, shown as citation rings in
red . Chin MH 2009 and Stadtfeld M 2010 at the bottom area of the cluster represent a theme that
differs from other themes of the cluster
8.2.4
Emerging Trends
Two articles of particular interest appear at the lower end of Cluster #7, Chin et al.
( 2009 ) and Stadtfeld et al. ( 2010 ). Chin et al.'s article has 158 citations within
the dataset. A citation burst was detected for Chin 2009 since 2010. Chin et al.
questioned whether induced pluripotent stem cells (iPSCs) are indistinguishable
from embryonic stem cells (ESCs). Their investigation suggested that iPSCs should
be considered as a unique subtype of pluripotent cell.
The co-citation network analysis has identified several articles that cite the work
by Chin et al. In order to establish whether Chin et al. represents the beginning of
a new emerging trend, we inspect these citing articles listed in Table 8.9 . Stadtfeld
2010 is the most cited citing article by itself with 134 citations. Similarly to Chin
et al., Stadtfeld 2010 addresses the question whether iPSCs are molecularly and
functionally equivalent to blastocyst-derived embryonic stem cells. Their work
identified the role of Dlk1-Dio3 gene cluster in association with the level of induced
pluripotency. In other words, these studies focus on mechanisms that govern induced
pluripotency, which can be seen as a distinct trend from the earlier trend on
improving reprogramming techniques. Table 8.9 includes two review articles cited
by Stadtfeld 2010.
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