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Fig. 8.6
Major areas of regenerative medicine
The 3,875 records do not include relevant publications if the term “regenerative
medicine” does not explicitly appear in the titles, abstracts, or index terms. We
expanded the dataset by citation indexing. If an article cites at least one of the 3,875
records, then the article will be included in the expanded dataset based on the as-
sumption that citing a regenerative medicine article makes the citing article relevant
to the topic. The citation index-based expansion resulted in 35,963 records, con-
sisting of 28,252 (78.6 %) original articles and 7,711 (21.4 %) review articles. The
range of the expanded set remains to be 2000-2011. Thus the analysis focuses on
the development of regenerative medicine over the last decade. The 35,963-article
dataset is used in the subsequent analysis. Incorrect citation variants to the two
highly visible references, a 1998 landmark article by Thomson et al. (
1998
)anda
1999 article by Pittenger (Pittenger et al.
1999
), were corrected prior to the analysis.
8.2.2
The Structure and Dynamics
Figure
8.6
shows a visualization of the literature relevant to regenerative medicine.
This visualization provides an overview of major milestones in history. The concen-
trations of colors indicate the chronological order of the development. For example,
cluster #12 mesenchymal stem cell was one of the earlier focuses of the research,
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