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Fig. 7.16
Articles cited more than 50 times during this period are labeled. Articles labeled
1
-
3
directly address the BSE-CJD connection. Article
4
is Prusiner's original article on prion, which
has broad implications on brain diseases in sheep, cattle, and human
•
Collinge, J., Sidle, K., Meads, J., Ironside, J., & Hill, A. (1996). Molecular
analysis of prion strain variation and the aetiology of 'new variant' CJD.
Nature,
383
, 685-691.
•
Bruce, M. E., Will, R. G., Ironside, J. W., McConnell, I., Drummond, D., Suttie,
A., McCardle, L., Chree, A., Hope, J., Birkett, C., Cousens, S., Fraser, H., &
Bostock, C. J. (1997). Transmissions to mice indicate that 'new variant' CJD is
caused by the BSE agent.
Nature, 389
(6650), 498-501.
•
Prusiner, S. B. (1982). Novel Proteinaceous Infectious Particles Cause Scrapie.
Science, 216
(4542), 136-144.
Research by Moira Bruce at the Neuropathogenesis Unit in Edinburgh has
confirmed that sheep can produce a range of prion particles but finding the one
that causes BSE has eluded researchers until now. There is no evidence that people
can catch BSE directly from eating sheep but most research has focused on cattle so
the possibility cannot be ruled out. Such a discovery would also devastate consumer
confidence.
According to Bruce et al. “Twenty cases of a clinically and pathologically
atypical form of Creutzfeldt-Jakob disease (CJD), referred to as 'new variant' CJD
(vCJD), have been recognized in unusually young people in the United Kingdom,
and a further case has been reported in France. This has raised serious concerns that
BSE may have spread to humans, putatively by dietary exposure.”
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