Biology Reference
In-Depth Information
cells (Herman
et al.
, 1985, Durum
et al.
, 1985). Thus, the authors
hypothesized that the generated IL-1β was the agent responsible for
agrimoniin's tumoricidal activities through stimulation of monocytes,
macrophages, and NK cells.
6.2.2.2
Other ellagitannins
Oenothein B (
67
, Fig. 6.13) has been isolated from several plants
including
Lythrum anceps
,
Oenothera erythrosepala
Bordas, the Central
European medicinal plant
Epilobium parviflorum
, the Mexican
Cuphea
hyssopifolia
Humb. Bompl. Et Kunth, the American
Quercus rubra
(red
oak) and
Epilobium
angustifolium
L. (willow herb), and the Asian
Melaleuca leucadendron
L.,
Eugenia uniflora
,
Eucalyptus alba
Reinw,
and
Woodfordia fruticosa
Kurz (Hatano
et al.
, 1989, 1990, Yoshida
et
al.
, 1989d, 1990, 1991, 1992, 1996, Okuda
et al.
, 1993, Lesuisse
et al.
,
1996, Chen
et al.
, 1999, Lee
et al.
, 2000, Barbehenn
et al.
, 2006a/b, Kiss
et al.
, 2004). Similarly to agrimoniin, oenothein B induced an increase in
the number of PEC cells and caused the adherent PECs (macrophages) to
inhibit the growth of MM2 and Meth-A tumor cells (Miyamoto
et al.
,
1993b/c). Furthermore, macrophages that were incubated with oenothein
B released IL-1β. This macrocyclic ellagitannin (10 μg/mL) induced
1010 pg/mL of IL-1β secretion whereas the control (no tannin) induced
only 295 pg/mL. As a positive control,
E. coli
LPS at 10 μg/mL led to
the release of 1230 pg/mL of IL-1β. A reevaluation of the antitumor
effect of oenothein B found that it was significantly more potent that
previously thought when given by intraperitoneal injection 4 days
before administration of sarcoma-180 (4 regressors out of 6 mice and
196 %ILS) or MM2 (5 regressors out of 6 mice and 9.3 %ILS) tumor
cells at a 10 mg/kg dose (Miyamoto
et al.
, 1993a-c).
In addition to its antitumor properties, oenothein B has been reported
to inhibit 5-α-reductase (IC
50
0.22 μM), neutral endopeptidase (IC
50
20
μM), herpes simplex virus absorption into cells (ED
50
0.036 μg/mL),
Epstein-Barr virus DNA polymerase (IC
50
62.3 μM), and poly(ADP-
ribose) glycohydrolase (IC
50
4.8 μM)
(Lesuisse
et al.
, 1996, Kiss
et al.
,
2004, Lee
et al.
, 2000, Fukuchi
et al.
, 1989, Aoki
et al.
, 1993, Maruta
et al.
, 2007). Furthermore, it has exhibited antileishmanial properties
