Biology Reference
In-Depth Information
as ER-112022 (
9
) also have shown agonistic activity through the TLR4
receptor without the need for CD14 (Lien
et al.
, 2001).
NHBz
AcO
O
Ph
O
OH
HO
O
O
O
Taxol (
7
)
HO
H
NH
HN
O
BzO
OAc
O
HO
O
O
P
O
O
P
O
O
(HO)
2
P
OH
HO
O
O
H
O
NH
O
ER-112022 (
9
)
O
HN
NH
O
O
O
O
HO
O
O
O
O
O
O
O
O
GLA-60 (
8
)
Fig. 6.5 Some LPS agonists.
6.1.4.2
LPS antagonists
There are considerably more reports of LPS antagonists than LPS
agonists in the literature (Black
et al.
, 1997b, Newton and Decicco,
1999, Paul
et al.
, 2006). One of the earliest approaches to developing
LPS antagonists relied on analogues of active lipid A itself. These
analogues competitively inhibited LPS/lipid A binding to the
TLR4/CD14 receptor complex. For example, the lipid A's of the non-
pathogenic Gram-negative bacteria
Rhodobacter capsulatus
(
10
) and
